Scientific Publications

A sensor for the detection of Alzheimer’s disease

The secondary structure of Aβ protein is a blood biomarker for Alzheimer’s disease

Development of a reusable surface coating

Publications

NumberTitleAuthorsJournalYearDOILink
240Amyloid-beta misfolding as a plasma biomarker indicates risk for future clinical Alzheimer´s disease in individuals with subjective cognitive declineStockmann, J., Verberk, I.M.W., Timmesfeld, N., Denz, R., Budde, B., Lange-Leifhelm, J., Scheltens, P., van der Flier, W., Nabers, A., Teunissen, C.E., Gerwert, K.Alzheimer's Research & Therapy2020DOI LinkLink
239Label-free vibrational imaging of different Abeta plaque types in Alzheimer´s disease reveals sequential events in plaque developmentRöhr, D., Boon, B.D.C., Schuler, M., Kremer, K., Hoozemans, J.J.M., Bouwman, F.H., El-Mashtoly, S.F., Nabers, A., Groserueschkamp, F., Rozemuller, A.M.J., Gerwert, K.Acta Neuropathol Commun2020DOI LinkLink
238TDP-43 as structure-based biomarker in amyotrophic lateral sclerosisBeyer, L., Günther, R., Koch, J.C., Klebe, S., Hagenacker, T., Lingor, P., Biesalski, A.-S., Hermann, A., Nabers, A., Gold, R., Tönges, L., Gerwert, K.Annals of Clinical and Translational Neurology2020DOI LinkLink
235The Effect of (-)-Epigallocatechin-3-Gallate on the Amyloid-beta Secondary StructureAcharya, A., Stockmann, J., Beyer, L., Rudack, T., Nabers, A., Gumbart, J.C., Gerwert, K., Batista, V.S.Biophys J.2020DOI LinkLink
233Struktur-Biomarker zur Früherkennung von Morbus AlzheimerStockmann, J., Gerwert, K.Biospektrum2020DOI LinkLink
227Prediction of Alzheimer's disease diagnosis within 14 years through Abeta misfolding in blood plasma compared to APOE4 status, and other risk factors.Stocker, H., Nabers, A., Perna, L., Möllers, T., Rujescu, D., Hartmann, A., Holleczek, B., Schöttker, B., Gerwert, K., Brenner, H.Alzheimer's & Dementia2019DOI LinkLink
224Reversible Immuno-Infrared Sensor for the Detection of Alzheimer's Disease Related BiomarkersBudde, B., Schartner, J., Tönges, L., Kötting, C., Nabers, A., Gerwert, K.ACS Sensors2019DOI LinkLink
221Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.Shahmoradian, S.H., Lewis, A.J., Genoud, C., Hench, J., Moors, T.E., Navarro, P.P., Castaño-Díez, D., Schweighauser, G., Graff-Meyer, A., Goldie, K.N., Sütterlin, R.,Huisman, E., Ingrassia, A., de Gier, Y., Rozemuller, A.J.M., Wang, J., De Paepe, A., Erny J., Staempfli, A., Hoernschemeyer, J., Großerüschkamp, F., Niedieker, D., El-Mashtoly, S.F., Quadri, M., Van IJcken, W.F.J., Bonifati, V., Gerwert, K., Bohrmann, B., Frank, S., Britschgi, M., Stahlberg, H., Van de Berg, W.D.J., Lauer, M.E.Nature Neuroscience2019DOI LinkLink
217Aß and tau structure-based biomarkers for a blood- and CSF-based two-step recruitment strategy to identify patients with dementia due to Alzheimer's diseaseNabers, A., Hafermann, H., Wiltfang, J., Gerwert, K.Alzheimer's & Dementia: Diagn., Assess. & Dis. Monit.2019DOI LinkLink
206Highly stable Protein Immobilization via Maleimido-Thiol Chemistry to Monitor Enzymatic ActivitySchartner, J., Güldenhaupt, J., Gaßmeyer, S.K., Rosga, K., Kourist, R., Gerwert, K., Kötting, C.Analyst2018DOI LinkLink
203Amyloid blood biomarker detects Alzheimer's diseaseNabers, A., Perna, L., Lange, J., Mons, U., Schartner, J., Güldenhaupt, J., Saum, K.-U., Janelidze, S., Holleczek, B., Rujescu, D., Hansson, O., Gerwert, K., Brenner, H.EMBO Molecular Medicine2018DOI LinkLink
197Lewy pathology in Parkinson's disease consists of a crowded organellar membranous medleyShahmoradian, S.H., Genoud, C., Graff-Meyer, A., Hench, J., Moors, T., Schweighauser, G., Wang, J., Goldie, K.N., Suetterlin, R., Castano-Diez, D., Perez-Navarro, P., Huisman, E., Ipsen, S., Ingrassia, A., de Gier, Y., Rozemuller, A.J.M., Da Paepe, A., Erny, J., Staempfli, A., Hoernschemeyer, J., Grosserueschkamp, F., Niedieker, D., El-Mashtoly, S.F., Quadri, M., van Ijcken, W.F.J., Bonifati, V., Gerwert, K., Bohrmann, B., Frank, B., Britschgi, M., Stahlberg, H., van de Berg, W., Lauer, M.E.bioRxiv2017DOI LinkLink
196An ATR-FTIR-Sensor Unraveling the Drug Intervention of Methylene Blue, Congo Red, and Berberine on Human Tau and AßSchartner, J., Nabers, A., Budde, B., Lange, J., Hoeck, N., Wiltfang, J., Kötting, C., Gerwert, K.ACS Medicinal Chemistry Letters2017DOI LinkLink
179Amyloid-ß-Secondary Structure Distribution in Cerebrospinal Fluid and Blood Measured by an Immuno-Infrared-Sensor: A Biomarker Candidate for Alzheimer's Disease.Nabers, A., Ollesch, J., Schartner, J., Kötting, C., Genius, J., Hafermann, H., Klafki, H., Gerwert, K., Wiltfang, J.Analytical Chemistry2016DOI LinkLink
178An infrared sensor analysing label-free the secondary structure of the Abeta peptide in presence of complex fluidsNabers, A., Ollesch, J., Schartner, J., Kötting, C., Genius, J., Haußmann, U., Klafki, H., Wiltfang, J., Gerwert, K.Journal of Biophotonics2016DOI LinkLink
173Chemical Functionalization of Germanium with Dextran-Brushes for Immobilization of Proteins Revealed by ATR-FTIR Difference SpectroscopySchartner, J., Hoeck, N., GÃ_ldenhaupt, J., Mavarani, L., Nabers, A., Gerwert, K., Kötting, C.Analytical Chemistry2015DOI LinkLink
165Immobilization of proteins in their physiological active state via functionalized thiol monolayers on ATR-germanium crystalsSchartner, J., Gavriljuk, K., Nabers, A., Weide, P., Muhler, M., Gerwert, K., Kötting, C.ChemBioChem2014DOI LinkLink
154FTIR spectroscopy of biofluids revisited: an automated approach to spectral biomarker identificationOllesch, J., Drees, S.L., Heise, H.M., Behrens, T., Brüning, T., Gerwert, K.Analyst2013DOI LinkLink
149Universal Method for Protein Immobilization on Chemically Functionalized Germanium Investigated by ATR-FTIR Difference SpectroscopySchartner, J., Güldenhaupt, J., Mei, B., Rögner, M., Muhler, M., Gerwert, K., Kötting, C.Journal of the American Chemical Society (JACS)2013DOI LinkLink

Patents

1.  Biosensor for conformation and secondary structure analysis

2.  Method for the Preselection of Drugs for Protein Misfolding Diseases

3.  Combined Assay for the Differential Diagnosis of the Alzheimer’s Disease